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KMID : 0370219970410040433
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Yakhak Hoeji
1997 Volume.41 No. 4 p.433 ~ p.438
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Isolation of Anguillosporal , a Potent Inhibitor of Phospholipase C from Fungi Isolate No. 51005
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오원근/Oh WK
이현선/안순철/고학룡/김보연/민태익/안종석/Lee HS/Ahn SC/Ko HR/Kim BY/Mheen TI/Ahn JS
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Abstract
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MT 51005 as a potent inhibitor of phospholipase C(PLC) was purified from the culture broth of a fungal strain No. 51005 isolated from soil. It was identified as a benzaldehyde d erivative, anguillosporal. by the physico-chemical properties and spectroscopic data. Anguillosporal showed the inhibitory activity against purified PLC with an IC50 of 13mcg/ml. And it also inhibited the formation of inositol phosphates(IPt) in platelet-derived growth factor(PDGF)-stimulated NIH3T3gamma1 cells with an IC50 of 0.8mcg/ml.
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